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desvenlafaxine will enhance the amount or influence of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Keep track of. Desvenlafaxine inhibits CYP2D6; with larger desvenlafaxine doses (ie, 400 mg) reduce the CYP2D6 substrate dose by as many as fifty%; no dosage adjustment wanted with desvenlafaxine doses seven consecutive days rig

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